KMID : 1100720160360060595
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Annals of Laboratory Medicine 2016 Volume.36 No. 6 p.595 ~ p.598
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Reference Intervals for Plasma Amyloid ¥â in Korean Adults Without Cognitive Impairment
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Kim Min-Young
Kim Kyu-Nam Cho Hye-Min Lee Duck-Joo Cho Doo-Yeoun
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Abstract
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Amyloid ¥â (A¥â) peptides are important components of plaques in patients with Alzheimer¡¯s disease (AD). Recent studies suggest that a low plasma ratio of A¥â42 to A¥â40 may precede the development of the sporadic form of AD. The aim of this study was to establish reference intervals for plasma A¥â in Korean adults. A total of 370 apparently healthy individuals (181 males and 189 females aged 40-69 yr) without cognitive impairment were enrolled. Plasma concentrations of A¥â40 and A¥â42 were measured by using a human amyloid ¥â assay kit (Immuno-Biological Laboratories, Japan). Reference intervals were established according to the ¡°CLSI guidelines for defining, establishing, and verifying reference intervals in the clinical laboratory¡±. There was no need to partition the data with respect to gender or age group. The 95th percentile reference intervals for A¥â40 and A¥â42 were 127-331 pg/mL and 2.31-19.84 pg/mL, respectively. The reference interval for the A¥â42/A¥â40 ratio was 0.011-0.092. Plasma A¥â concentrations obtained in this study could be used as reference intervals for clinical purposes.
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KEYWORD
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Reference interval, Amyloid ¥â, Plasma concentration, Alzheimer¡¯s disease
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